Among the substances listed, which has the longest typical duration according to the material?

Among the substances listed, which has the longest typical duration according to the material?

• A. PCP Angel Dust (up to days when injected)
• B. Cocaine (1-2 hours)
• C. Amphetamines (2-4 hours)
• D. Ice (4-14 hours)

Answer: (A)

Duration of effects hinges on pharmacokinetics—how the body absorbs, distributes, metabolizes, and eliminates a drug. PCP stands out for lasting much longer than the others because it is highly lipid-soluble and readily partitions into tissues, including fat. After an injection, the drug floods the brain and then slowly leaches out of these tissue reservoirs back into the bloodstream, keeping blood levels elevated for an extended period. This tissue storage and slow release keep PCP’s effects going for days, far longer than cocaine (about 1–2 hours), amphetamines (roughly 2–4 hours), or ice/crystal meth (about 4–14 hours).

Duration of effects hinges on pharmacokinetics—how the body absorbs, distributes, metabolizes, and eliminates a drug. PCP stands out for lasting much longer than the others because it is highly lipid-soluble and readily partitions into tissues, including fat. After an injection, the drug floods the brain and then slowly leaches out of these tissue reservoirs back into the bloodstream, keeping blood levels elevated for an extended period. This tissue storage and slow release keep PCP’s effects going for days, far longer than cocaine (about 1–2 hours), amphetamines (roughly 2–4 hours), or ice/crystal meth (about 4–14 hours).